full transcript

From the Ted Talk by Christopher Bahl: A new type of medicine, custom-made with tiny proteins

Unscramble the Blue Letters


So this is where I come in. Creating a new drug is a lot like crafting a key to fit a particular lock. We need to get the shape just right. But if we change the shape of a constrained peptide by too much, those extra chemical bdnos are unable to form and the whole mllcuoee falls apart. So we needed to figure out how to gain control over their shape.

I was part of a crvtolbliaoae scientific effort that spanned a dozen institutions across three continents that came together and solved this problem. We took a rlacalidy different aapocrph from previous eftfors. Instead of mnkiag changes to the constrained peptides that we find in nature, we figured out how to bliud new ones totally from scratch. To help us do this, we developed freely available open-source peptide-design software that anyone can use to do this, too.

Open Cloze


So this is where I come in. Creating a new drug is a lot like crafting a key to fit a particular lock. We need to get the shape just right. But if we change the shape of a constrained peptide by too much, those extra chemical _____ are unable to form and the whole ________ falls apart. So we needed to figure out how to gain control over their shape.

I was part of a _____________ scientific effort that spanned a dozen institutions across three continents that came together and solved this problem. We took a _________ different ________ from previous _______. Instead of ______ changes to the constrained peptides that we find in nature, we figured out how to _____ new ones totally from scratch. To help us do this, we developed freely available open-source peptide-design software that anyone can use to do this, too.

Solution


  1. build
  2. radically
  3. approach
  4. molecule
  5. collaborative
  6. efforts
  7. bonds
  8. making

Original Text


So this is where I come in. Creating a new drug is a lot like crafting a key to fit a particular lock. We need to get the shape just right. But if we change the shape of a constrained peptide by too much, those extra chemical bonds are unable to form and the whole molecule falls apart. So we needed to figure out how to gain control over their shape.

I was part of a collaborative scientific effort that spanned a dozen institutions across three continents that came together and solved this problem. We took a radically different approach from previous efforts. Instead of making changes to the constrained peptides that we find in nature, we figured out how to build new ones totally from scratch. To help us do this, we developed freely available open-source peptide-design software that anyone can use to do this, too.

Frequently Occurring Word Combinations


ngrams of length 2

collocation frequency
constrained peptides 8
constrained peptide 5
drug development 4
peptide drugs 3
extra chemical 2
chemical bonds 2
biologic drugs 2
development pipeline 2

ngrams of length 3

collocation frequency
constrained peptide drugs 2
extra chemical bonds 2
drug development pipeline 2

Important Words


  1. approach
  2. bonds
  3. build
  4. change
  5. chemical
  6. collaborative
  7. constrained
  8. continents
  9. control
  10. crafting
  11. creating
  12. developed
  13. dozen
  14. drug
  15. effort
  16. efforts
  17. extra
  18. falls
  19. figure
  20. figured
  21. find
  22. fit
  23. form
  24. freely
  25. gain
  26. institutions
  27. key
  28. lock
  29. lot
  30. making
  31. molecule
  32. nature
  33. needed
  34. part
  35. peptide
  36. peptides
  37. previous
  38. problem
  39. radically
  40. scientific
  41. scratch
  42. shape
  43. software
  44. solved
  45. spanned
  46. totally
  47. unable