full transcript

From the Ted Talk by Molly Stevens: A new way to grow bone

Unscramble the Blue Letters


So what we were tkinihng is, there's a tremendous need for bone repair, of course, but this iliac crest-type approach really has a lot of laiitiotnms to it, and could we perhaps recreate the generation of bone within the body on demand and then be able to transplant it without these very, very painful aftereffects that you would have with the iliac crest harvest?

And so this is what we did, and the way we did it was by coming back to this tiycapl tissue-engineering approach but actually thinking about it rather differently. And we simplified it a lot, so we got rid of a lot of these steps. We got rid of the need to harvest cells from the patient, we got rid of the need to put in really fancy cmiihtrsees, and we got rid of the need to culture these scaffolds in the lab. And what we really focused on was our metiraal system and making it quite smpile, but because we used it in a really clever way, we were able to generate enormous amounts of bone using this arappoch. So we were using the body as really the csylaatt to help us to make lots of new bone. And it's an approach that we call the in vivo bioreactor, and we were able to make eoruonms amounts of bone using this approach. And I'll talk you through this.

Open Cloze


So what we were ________ is, there's a tremendous need for bone repair, of course, but this iliac crest-type approach really has a lot of ___________ to it, and could we perhaps recreate the generation of bone within the body on demand and then be able to transplant it without these very, very painful aftereffects that you would have with the iliac crest harvest?

And so this is what we did, and the way we did it was by coming back to this _______ tissue-engineering approach but actually thinking about it rather differently. And we simplified it a lot, so we got rid of a lot of these steps. We got rid of the need to harvest cells from the patient, we got rid of the need to put in really fancy ___________, and we got rid of the need to culture these scaffolds in the lab. And what we really focused on was our ________ system and making it quite ______, but because we used it in a really clever way, we were able to generate enormous amounts of bone using this ________. So we were using the body as really the ________ to help us to make lots of new bone. And it's an approach that we call the in vivo bioreactor, and we were able to make ________ amounts of bone using this approach. And I'll talk you through this.

Solution


  1. enormous
  2. limitations
  3. material
  4. approach
  5. simple
  6. catalyst
  7. thinking
  8. chemistries
  9. typical

Original Text


So what we were thinking is, there's a tremendous need for bone repair, of course, but this iliac crest-type approach really has a lot of limitations to it, and could we perhaps recreate the generation of bone within the body on demand and then be able to transplant it without these very, very painful aftereffects that you would have with the iliac crest harvest?

And so this is what we did, and the way we did it was by coming back to this typical tissue-engineering approach but actually thinking about it rather differently. And we simplified it a lot, so we got rid of a lot of these steps. We got rid of the need to harvest cells from the patient, we got rid of the need to put in really fancy chemistries, and we got rid of the need to culture these scaffolds in the lab. And what we really focused on was our material system and making it quite simple, but because we used it in a really clever way, we were able to generate enormous amounts of bone using this approach. So we were using the body as really the catalyst to help us to make lots of new bone. And it's an approach that we call the in vivo bioreactor, and we were able to make enormous amounts of bone using this approach. And I'll talk you through this.

Frequently Occurring Word Combinations


ngrams of length 2

collocation frequency
stem cells 6
iliac crest 3
blue nacre 2
nacre shell 2
crest harvest 2
enormous amounts 2
original bone 2
beautifully organized 2
blood vessels 2
developing materials 2

ngrams of length 3

collocation frequency
blue nacre shell 2
iliac crest harvest 2

Important Words


  1. aftereffects
  2. amounts
  3. approach
  4. bioreactor
  5. body
  6. bone
  7. call
  8. catalyst
  9. cells
  10. chemistries
  11. clever
  12. coming
  13. crest
  14. culture
  15. demand
  16. differently
  17. enormous
  18. fancy
  19. focused
  20. generate
  21. generation
  22. harvest
  23. iliac
  24. lab
  25. limitations
  26. lot
  27. lots
  28. making
  29. material
  30. painful
  31. patient
  32. put
  33. recreate
  34. repair
  35. rid
  36. scaffolds
  37. simple
  38. simplified
  39. steps
  40. system
  41. talk
  42. thinking
  43. transplant
  44. tremendous
  45. typical
  46. vivo