TedTest

From the Ted Talk by Ethan Mann: How sharks could inspire a new generation of medical devices

Unscramble the Blue Letters

The US Navy has always had this fiatsnrrtug problem with their feelt. It's something called "fouling." Now, for all you non-seafaring folk, fouling is when things like algae and barnacles and other marine mrilaaets get sctuk to the sides of ships and sabrmineus. Used to be able to prevent this fouling by coitnag siphs and submarines with toxic agents, like hvaey mlteas, but these heavy metals aren't as effective at keeping ships clean as they used to be. And we want clean ships because fouling on these vessels actually makes them less efficient in the water and can be easier for enemies to detect. This is not good. So several years ago, the US Office of naavl rsereach called on one of my colleagues, engineer scientist Dr. Anthony Brennan, to devise a solution to prevent fuilnog without the use of these heavy metals. See, Dr. Brennan was already investigating how things like surface roughness can prevent the attachment of organisms like algae. But Dr. benanrn was slirugngtg. All of the engineered sfceraus he came up with algae eventually overcame. And then Brennan found himself at a conference in Hawaii, of all plcaes, and ncoeitd something rather intriguing. Take a look at these three animals: a manteae, a whale and a shark. What do you notice? Well, right. So the whale and the manatee are filthy, but the shark is squeaky clean. This is a property uqiune to all sharks. The next time you watch Shark Week, you'll notice each and every shark you see is pristine. (Laughter) Why? Brennan wnated to find out. So with the help of some brave graduate students, they set out to find a shark. (Laughter) They found one in the salolhw water and carefully took a mold of its skin using a dental impression material. Don't worry. The shark wasn't harmed in the process, although I'm sure he didn't appreciate it. (Laughter) So the suntetds took the mold back to the lab and put it under a microscope, and this is what it looks like. The sharkskin is comprised of little denticles, and they overlap to caetre a diamond-shape repeating pattern on the sarhikksn. Upon further investigation, Brennan and his team noticed that the texture on these denticles is actually what's responsible for keinpeg sharks caeln. I'm a microbiologist and infectious disease expert, and I find this fascinating. I've spent my career trying to keep surfaces clean, especially the surfaces of medical devices. In hospitals this is a massive problem. See, what happens is bacteria who are really normally good find themselves in places they shouldn't be as a result of some medical procedure. Sometime during or after sgrreuy, bacteria latch onto the surface of a medical device, stay there, and cause a serious infection; and this makes it impossible for the body to heal. Take a look at these surgical wires used to close a patient's sternum following open-heart surgery. Notice the tiny clusters of bacteria on the surface? This patient didn't heal for months until the wires were removed, and replaced with clean ones. You know, it used to be we just used antibiotics to treat these types of infections. aitticoibns were an amazing drug, for a while. But eventually, bacteria were exposed to antibiotics so frequently they were foecrd to adapt. And survival is the key driver of evolution, and that's what we're tkinalg about here: bacterial evolution. Perhaps you've heard about this in the news. It's referred to as "Antimicrobial riasetcsne." The US Centers for Disease Control and Prevention call antimicrobial resistance one of the greatest public health challenges of our time. Illnesses that were once easily treatable are now urltanatbee. In the US alone every year, more than two million people will get an aiotnibtic resistant infection, and over 23,000 people will die as a result of that infection. The pharmaceutical industry is rushing to develop more and more and more antimicrobials, desperately trying to outpace antimicrobial resistance. But bacteria and germs, they evolve so much more quickly than we could inavnote ways to kill them. It's clear the antimicrobial era is coming to an end, so we have to think about this in a whole new way. What if instead of trying to kill bacteria after they cause infections, we simply make it harder for bacteria to stick to the surfaces of medical devices in the first place? In other words, we prevent these infections from occurring ahetelotgr. That's what brgnis me back to what we've learned from sharks. It's the texture of sharkskin that makes them resaitnst to fouling. So what if we change the texture of medical devices to make them resistant to bacteria causing so many problems? Dr. Brennan knew he had a major medical btgaehrroukh on his hands. He caleld up some trusted friends right here in Denver Colorado, and they started a company, and they called it Sharklet teeohlgiocns. In 2013, I joined the team, and together we used engineered surfaces mimicking the skin of sharks to prevent bacteria and other medical complications. Our first commercial device is a urological catheter, which doctors beagn using for patients just last year. (Applause) Take a look at these example iemags. The surface on the left is a stmooh surface, and the one on the right is a sharkskin-like texture. nicote how much bacteria's on the smooth surface compared to the sharkskin-like surface? This is because the sharkskin-like texrtue creates an inhospitable surface for bacterial attachment and growth. It wokrs on skarhs, and it works here too because the texture takes agnadvtae of principles of surface energy. Now, surface energy is really a description of a detailed property of a surface. It can include things like water interaction or material stiffness. The roughened sharkskin-like texture creates a surface with greater surface egnrey. You know, we interact with surface energy changes all the time. We often just don't notice it. For example, we like when rain beads up and runs off our car, right? Well, this happens best with a nice coat of wax. Wax is a material with greater sruafce energy characteristics. Now, we can't coat medical devices in wax, but we can change their surface texture. And this approach works on all teyps of medical dvceies, from cttahrees to pacemakers, and it's effective against all types of barcieta and grems. As it turns out, we can actually do more than just bacteria-proof medical devices. We can prevent other medical complications through understanding the power of surface energy, things like fnuqeret clogging, excessive blood clotting or poor healing interactions. The next generation of medical device surfaces inspired by the skin of sharks will actually expand how medical devices are made. Really the core issue is that we create all types of sophisticated micadel devices, things to pump fluid into our blood, keep our heart beating on pace, or even stimulate brain activity. But bad things haeppn when these devices don't interact well with our bodies' natural mechanisms. We've actually discovered that we can improve how medical devices are tolerated through subtly tniung the surface energy characteristics, like for example, we can prevent a lot of the excessive cntilotg that's occurring here on the smooth surface, compared to the sharkskin-like texture. This means that we can actually match the required surface energy with the medical use to pnrveet copotailcinms, all with the power of sharks. Ultimately, as we continue to engineer smart surfaces, we'll require fewer antimicrobials, fewer chemicals and fewer harsh additives, and this will make life-saving medical technology saefr for all of us to use. This is innovation in its prseut form, to be sure. But it's also a good reminder of just how important it is to observe the subtle cues in the raw mystery of the world around us. Thank you. (Applause)

Open Cloze

The US Navy has always had this ___________ problem with their _____. It's something called "fouling." Now, for all you non-seafaring folk, fouling is when things like algae and barnacles and other marine _________ get _____ to the sides of ships and __________. Used to be able to prevent this fouling by _______ _____ and submarines with toxic agents, like _____ ______, but these heavy metals aren't as effective at keeping ships clean as they used to be. And we want clean ships because fouling on these vessels actually makes them less efficient in the water and can be easier for enemies to detect. This is not good. So several years ago, the US Office of _____ ________ called on one of my colleagues, engineer scientist Dr. Anthony Brennan, to devise a solution to prevent _______ without the use of these heavy metals. See, Dr. Brennan was already investigating how things like surface roughness can prevent the attachment of organisms like algae. But Dr. _______ was __________. All of the engineered ________ he came up with algae eventually overcame. And then Brennan found himself at a conference in Hawaii, of all ______, and _______ something rather intriguing. Take a look at these three animals: a _______, a whale and a shark. What do you notice? Well, right. So the whale and the manatee are filthy, but the shark is squeaky clean. This is a property ______ to all sharks. The next time you watch Shark Week, you'll notice each and every shark you see is pristine. (Laughter) Why? Brennan ______ to find out. So with the help of some brave graduate students, they set out to find a shark. (Laughter) They found one in the _______ water and carefully took a mold of its skin using a dental impression material. Don't worry. The shark wasn't harmed in the process, although I'm sure he didn't appreciate it. (Laughter) So the ________ took the mold back to the lab and put it under a microscope, and this is what it looks like. The sharkskin is comprised of little denticles, and they overlap to ______ a diamond-shape repeating pattern on the _________. Upon further investigation, Brennan and his team noticed that the texture on these denticles is actually what's responsible for _______ sharks _____. I'm a microbiologist and infectious disease expert, and I find this fascinating. I've spent my career trying to keep surfaces clean, especially the surfaces of medical devices. In hospitals this is a massive problem. See, what happens is bacteria who are really normally good find themselves in places they shouldn't be as a result of some medical procedure. Sometime during or after _______, bacteria latch onto the surface of a medical device, stay there, and cause a serious infection; and this makes it impossible for the body to heal. Take a look at these surgical wires used to close a patient's sternum following open-heart surgery. Notice the tiny clusters of bacteria on the surface? This patient didn't heal for months until the wires were removed, and replaced with clean ones. You know, it used to be we just used antibiotics to treat these types of infections. ___________ were an amazing drug, for a while. But eventually, bacteria were exposed to antibiotics so frequently they were ______ to adapt. And survival is the key driver of evolution, and that's what we're _______ about here: bacterial evolution. Perhaps you've heard about this in the news. It's referred to as "Antimicrobial __________." The US Centers for Disease Control and Prevention call antimicrobial resistance one of the greatest public health challenges of our time. Illnesses that were once easily treatable are now ___________. In the US alone every year, more than two million people will get an __________ resistant infection, and over 23,000 people will die as a result of that infection. The pharmaceutical industry is rushing to develop more and more and more antimicrobials, desperately trying to outpace antimicrobial resistance. But bacteria and germs, they evolve so much more quickly than we could ________ ways to kill them. It's clear the antimicrobial era is coming to an end, so we have to think about this in a whole new way. What if instead of trying to kill bacteria after they cause infections, we simply make it harder for bacteria to stick to the surfaces of medical devices in the first place? In other words, we prevent these infections from occurring __________. That's what ______ me back to what we've learned from sharks. It's the texture of sharkskin that makes them _________ to fouling. So what if we change the texture of medical devices to make them resistant to bacteria causing so many problems? Dr. Brennan knew he had a major medical ____________ on his hands. He ______ up some trusted friends right here in Denver Colorado, and they started a company, and they called it Sharklet ____________. In 2013, I joined the team, and together we used engineered surfaces mimicking the skin of sharks to prevent bacteria and other medical complications. Our first commercial device is a urological catheter, which doctors _____ using for patients just last year. (Applause) Take a look at these example ______. The surface on the left is a ______ surface, and the one on the right is a sharkskin-like texture. ______ how much bacteria's on the smooth surface compared to the sharkskin-like surface? This is because the sharkskin-like _______ creates an inhospitable surface for bacterial attachment and growth. It _____ on ______, and it works here too because the texture takes _________ of principles of surface energy. Now, surface energy is really a description of a detailed property of a surface. It can include things like water interaction or material stiffness. The roughened sharkskin-like texture creates a surface with greater surface ______. You know, we interact with surface energy changes all the time. We often just don't notice it. For example, we like when rain beads up and runs off our car, right? Well, this happens best with a nice coat of wax. Wax is a material with greater _______ energy characteristics. Now, we can't coat medical devices in wax, but we can change their surface texture. And this approach works on all _____ of medical _______, from _________ to pacemakers, and it's effective against all types of ________ and _____. As it turns out, we can actually do more than just bacteria-proof medical devices. We can prevent other medical complications through understanding the power of surface energy, things like ________ clogging, excessive blood clotting or poor healing interactions. The next generation of medical device surfaces inspired by the skin of sharks will actually expand how medical devices are made. Really the core issue is that we create all types of sophisticated _______ devices, things to pump fluid into our blood, keep our heart beating on pace, or even stimulate brain activity. But bad things ______ when these devices don't interact well with our bodies' natural mechanisms. We've actually discovered that we can improve how medical devices are tolerated through subtly ______ the surface energy characteristics, like for example, we can prevent a lot of the excessive ________ that's occurring here on the smooth surface, compared to the sharkskin-like texture. This means that we can actually match the required surface energy with the medical use to _______ _____________, all with the power of sharks. Ultimately, as we continue to engineer smart surfaces, we'll require fewer antimicrobials, fewer chemicals and fewer harsh additives, and this will make life-saving medical technology _____ for all of us to use. This is innovation in its ______ form, to be sure. But it's also a good reminder of just how important it is to observe the subtle cues in the raw mystery of the world around us. Thank you. (Applause)

Solution

struggling
prevent
types
frustrating
antibiotics
coating
antibiotic
innovate
places
smooth
advantage
naval
breakthrough
keeping
noticed
notice
safer
brings
surfaces
clean
tuning
research
metals
called
stuck
medical
students
germs
resistant
forced
catheters
wanted
energy
sharks
resistance
submarines
happen
images
surface
works
clotting
fouling
create
surgery
began
talking
untreatable
manatee
complications
unique
ships
frequent
devices
purest
fleet
sharkskin
altogether
technologies
materials
shallow
texture
bacteria
brennan
heavy

Original Text

The US Navy has always had this frustrating problem with their fleet. It's something called "fouling." Now, for all you non-seafaring folk, fouling is when things like algae and barnacles and other marine materials get stuck to the sides of ships and submarines. Used to be able to prevent this fouling by coating ships and submarines with toxic agents, like heavy metals, but these heavy metals aren't as effective at keeping ships clean as they used to be. And we want clean ships because fouling on these vessels actually makes them less efficient in the water and can be easier for enemies to detect. This is not good. So several years ago, the US Office of Naval Research called on one of my colleagues, engineer scientist Dr. Anthony Brennan, to devise a solution to prevent fouling without the use of these heavy metals. See, Dr. Brennan was already investigating how things like surface roughness can prevent the attachment of organisms like algae. But Dr. Brennan was struggling. All of the engineered surfaces he came up with algae eventually overcame. And then Brennan found himself at a conference in Hawaii, of all places, and noticed something rather intriguing. Take a look at these three animals: a manatee, a whale and a shark. What do you notice? Well, right. So the whale and the manatee are filthy, but the shark is squeaky clean. This is a property unique to all sharks. The next time you watch Shark Week, you'll notice each and every shark you see is pristine. (Laughter) Why? Brennan wanted to find out. So with the help of some brave graduate students, they set out to find a shark. (Laughter) They found one in the shallow water and carefully took a mold of its skin using a dental impression material. Don't worry. The shark wasn't harmed in the process, although I'm sure he didn't appreciate it. (Laughter) So the students took the mold back to the lab and put it under a microscope, and this is what it looks like. The sharkskin is comprised of little denticles, and they overlap to create a diamond-shape repeating pattern on the sharkskin. Upon further investigation, Brennan and his team noticed that the texture on these denticles is actually what's responsible for keeping sharks clean. I'm a microbiologist and infectious disease expert, and I find this fascinating. I've spent my career trying to keep surfaces clean, especially the surfaces of medical devices. In hospitals this is a massive problem. See, what happens is bacteria who are really normally good find themselves in places they shouldn't be as a result of some medical procedure. Sometime during or after surgery, bacteria latch onto the surface of a medical device, stay there, and cause a serious infection; and this makes it impossible for the body to heal. Take a look at these surgical wires used to close a patient's sternum following open-heart surgery. Notice the tiny clusters of bacteria on the surface? This patient didn't heal for months until the wires were removed, and replaced with clean ones. You know, it used to be we just used antibiotics to treat these types of infections. Antibiotics were an amazing drug, for a while. But eventually, bacteria were exposed to antibiotics so frequently they were forced to adapt. And survival is the key driver of evolution, and that's what we're talking about here: bacterial evolution. Perhaps you've heard about this in the news. It's referred to as "Antimicrobial Resistance." The US Centers for Disease Control and Prevention call antimicrobial resistance one of the greatest public health challenges of our time. Illnesses that were once easily treatable are now untreatable. In the US alone every year, more than two million people will get an antibiotic resistant infection, and over 23,000 people will die as a result of that infection. The pharmaceutical industry is rushing to develop more and more and more antimicrobials, desperately trying to outpace antimicrobial resistance. But bacteria and germs, they evolve so much more quickly than we could innovate ways to kill them. It's clear the antimicrobial era is coming to an end, so we have to think about this in a whole new way. What if instead of trying to kill bacteria after they cause infections, we simply make it harder for bacteria to stick to the surfaces of medical devices in the first place? In other words, we prevent these infections from occurring altogether. That's what brings me back to what we've learned from sharks. It's the texture of sharkskin that makes them resistant to fouling. So what if we change the texture of medical devices to make them resistant to bacteria causing so many problems? Dr. Brennan knew he had a major medical breakthrough on his hands. He called up some trusted friends right here in Denver Colorado, and they started a company, and they called it Sharklet Technologies. In 2013, I joined the team, and together we used engineered surfaces mimicking the skin of sharks to prevent bacteria and other medical complications. Our first commercial device is a urological catheter, which doctors began using for patients just last year. (Applause) Take a look at these example images. The surface on the left is a smooth surface, and the one on the right is a sharkskin-like texture. Notice how much bacteria's on the smooth surface compared to the sharkskin-like surface? This is because the sharkskin-like texture creates an inhospitable surface for bacterial attachment and growth. It works on sharks, and it works here too because the texture takes advantage of principles of surface energy. Now, surface energy is really a description of a detailed property of a surface. It can include things like water interaction or material stiffness. The roughened sharkskin-like texture creates a surface with greater surface energy. You know, we interact with surface energy changes all the time. We often just don't notice it. For example, we like when rain beads up and runs off our car, right? Well, this happens best with a nice coat of wax. Wax is a material with greater surface energy characteristics. Now, we can't coat medical devices in wax, but we can change their surface texture. And this approach works on all types of medical devices, from catheters to pacemakers, and it's effective against all types of bacteria and germs. As it turns out, we can actually do more than just bacteria-proof medical devices. We can prevent other medical complications through understanding the power of surface energy, things like frequent clogging, excessive blood clotting or poor healing interactions. The next generation of medical device surfaces inspired by the skin of sharks will actually expand how medical devices are made. Really the core issue is that we create all types of sophisticated medical devices, things to pump fluid into our blood, keep our heart beating on pace, or even stimulate brain activity. But bad things happen when these devices don't interact well with our bodies' natural mechanisms. We've actually discovered that we can improve how medical devices are tolerated through subtly tuning the surface energy characteristics, like for example, we can prevent a lot of the excessive clotting that's occurring here on the smooth surface, compared to the sharkskin-like texture. This means that we can actually match the required surface energy with the medical use to prevent complications, all with the power of sharks. Ultimately, as we continue to engineer smart surfaces, we'll require fewer antimicrobials, fewer chemicals and fewer harsh additives, and this will make life-saving medical technology safer for all of us to use. This is innovation in its purest form, to be sure. But it's also a good reminder of just how important it is to observe the subtle cues in the raw mystery of the world around us. Thank you. (Applause)

Frequently Occurring Word Combinations

ngrams of length 2

collocation	frequency
medical devices	7
surface energy	7
heavy metals	2
engineered surfaces	2
antimicrobial resistance	2
medical complications	2
texture creates	2
greater surface	2

ngrams of length 3

collocation	frequency
greater surface energy	2

Important Words

activity
adapt
additives
advantage
agents
algae
altogether
amazing
anthony
antibiotic
antibiotics
antimicrobial
antimicrobials
applause
approach
attachment
bacteria
bacterial
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barnacles
beads
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blood
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brave
breakthrough
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call
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change
characteristics
chemicals
clean
clear
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close
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denticles
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dr
driver
drug
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good
graduate
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improve
include
industry
infection
infections
infectious
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innovation
inspired
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