full transcript
From the Ted Talk by Jay Bradner: Open-source cancer research
Unscramble the Blue Letters
And so we started to work on this problem. We developed libraries of cpuonmods and evutaenlly arrived at this and similar substances called JQ1. Now, not being a drug company, we could do certain things, we had certain flexibilities, that I respect that a pharmaceutical irtundsy doesn't have. We just started mailing it to our friends. I have a small lab. We tughhot we'd just send it to people and see how the molecule bvahees. We sent it to oxorfd, England, where a group of talented crystallographers provided this picture, which helped us understand exactly how this molecule is so potent for this protein target. It's what we call a prcefet fit of shape complementarity, or hand in glove.
Open Cloze
And so we started to work on this problem. We developed libraries of _________ and __________ arrived at this and similar substances called JQ1. Now, not being a drug company, we could do certain things, we had certain flexibilities, that I respect that a pharmaceutical ________ doesn't have. We just started mailing it to our friends. I have a small lab. We _______ we'd just send it to people and see how the molecule _______. We sent it to ______, England, where a group of talented crystallographers provided this picture, which helped us understand exactly how this molecule is so potent for this protein target. It's what we call a _______ fit of shape complementarity, or hand in glove.
Solution
- industry
- compounds
- behaves
- eventually
- thought
- perfect
- oxford
Original Text
And so we started to work on this problem. We developed libraries of compounds and eventually arrived at this and similar substances called JQ1. Now, not being a drug company, we could do certain things, we had certain flexibilities, that I respect that a pharmaceutical industry doesn't have. We just started mailing it to our friends. I have a small lab. We thought we'd just send it to people and see how the molecule behaves. We sent it to Oxford, England, where a group of talented crystallographers provided this picture, which helped us understand exactly how this molecule is so potent for this protein target. It's what we call a perfect fit of shape complementarity, or hand in glove.
Frequently Occurring Word Combinations
ngrams of length 2
collocation |
frequency |
rare cancer |
3 |
prototype drug |
3 |
drug substance |
2 |
discovery chemistry |
2 |
protein target |
2 |
chest tube |
2 |
clinical trial |
2 |
chemical identity |
2 |
Important Words
- arrived
- behaves
- call
- called
- company
- complementarity
- compounds
- crystallographers
- developed
- drug
- england
- eventually
- fit
- flexibilities
- friends
- glove
- group
- hand
- helped
- industry
- lab
- libraries
- mailing
- molecule
- oxford
- people
- perfect
- pharmaceutical
- picture
- potent
- problem
- protein
- respect
- send
- shape
- similar
- small
- started
- substances
- talented
- target
- thought
- understand
- work