full transcript

From the Ted Talk by Yoram Yovell: Why broken hearts hurt — and what heals them

Unscramble the Blue Letters


We discovered that tiny, tiny doses of buprenorphine, which are too low to treat physical pain, helped many of them become less suicidal. But nroatcics are extremely danuerogs drugs. They may cause addiction, and they're lethal in ooevrsde. In contrast, endorphins are not lethal in overdose, and they're much less likely to cause addiction. So narcotics and endorphins probably aacvttie mu opioid rpeotrecs in different ways.

Now, if we could find drugs that activate mu opioid receptors in a way that rembesles how endorphins activate them, we might be able to treat piasyhcl and mental pain without some of the dangerous side effects of narcotics. And when my research team came to this cuisclnoon, I suddenly remembered what I had learned in Kandel's lab many, many years ago.

Open Cloze


We discovered that tiny, tiny doses of buprenorphine, which are too low to treat physical pain, helped many of them become less suicidal. But _________ are extremely _________ drugs. They may cause addiction, and they're lethal in ________. In contrast, endorphins are not lethal in overdose, and they're much less likely to cause addiction. So narcotics and endorphins probably ________ mu opioid _________ in different ways.

Now, if we could find drugs that activate mu opioid receptors in a way that _________ how endorphins activate them, we might be able to treat ________ and mental pain without some of the dangerous side effects of narcotics. And when my research team came to this __________, I suddenly remembered what I had learned in Kandel's lab many, many years ago.

Solution


  1. overdose
  2. receptors
  3. resembles
  4. narcotics
  5. activate
  6. dangerous
  7. conclusion
  8. physical

Original Text


We discovered that tiny, tiny doses of buprenorphine, which are too low to treat physical pain, helped many of them become less suicidal. But narcotics are extremely dangerous drugs. They may cause addiction, and they're lethal in overdose. In contrast, endorphins are not lethal in overdose, and they're much less likely to cause addiction. So narcotics and endorphins probably activate mu opioid receptors in different ways.

Now, if we could find drugs that activate mu opioid receptors in a way that resembles how endorphins activate them, we might be able to treat physical and mental pain without some of the dangerous side effects of narcotics. And when my research team came to this conclusion, I suddenly remembered what I had learned in Kandel's lab many, many years ago.

Frequently Occurring Word Combinations


ngrams of length 2

collocation frequency
mental pain 17
mu opioid 13
opioid receptors 9
treat physical 5
research team 3
activate mu 3
human mu 3
natural remedy 2
severe physical 2
activating mu 2
tiny doses 2
side effects 2
virtual model 2
opioid receptor 2
existing drugs 2

ngrams of length 3

collocation frequency
mu opioid receptors 9
activate mu opioid 3
human mu opioid 3
activating mu opioid 2
mu opioid receptor 2

Important Words


  1. activate
  2. addiction
  3. buprenorphine
  4. conclusion
  5. contrast
  6. dangerous
  7. discovered
  8. doses
  9. drugs
  10. effects
  11. endorphins
  12. extremely
  13. find
  14. helped
  15. lab
  16. learned
  17. lethal
  18. mental
  19. mu
  20. narcotics
  21. opioid
  22. overdose
  23. pain
  24. physical
  25. receptors
  26. remembered
  27. research
  28. resembles
  29. side
  30. suddenly
  31. suicidal
  32. team
  33. tiny
  34. treat
  35. ways
  36. years